近日，清原农冠环吡氟草酮（cypyrafluone）等专利化合物获巴基斯坦农业部的批准登记，这是该系列产品在海外的首次登记，标志着清原农冠正式启动国外销售，进军海外市场。

       环吡氟草酮（cypyrafluone）是清原农冠自主创制的对羟苯基丙酮酸双氧化酶（HPPD）抑制剂类除草剂专利化合物，已于2018年8月30日获得中华人民共和国农业农村部正式登记。这是HPPD抑制剂首次用于小麦田防除禾本科杂草，与当前小麦田其它除草剂都不存在交互抗性。

环吡氟草酮结构式

环吡氟草酮获巴基斯坦批准登记

       清原农冠进军海外，巴基斯坦在亚洲市场上具有重要的战略意义。据了解，巴基斯坦是典型的农业国家，以种植业为主，粮食作物主要有小麦、水稻、玉米等，其中小麦种植面积约占全国耕地总面积的40%。但是农民备受小籽虉草（Phalaris minor）等杂草困扰，由于小籽虉草（Phalaris minor）对当地主流除草剂产生抗性，且长势强，繁殖系数高，传播速度快，严重影响巴基斯坦的农业生产。

清原农冠工作人员与当地农户交流田间杂草情况

       为提升世界农业生产的效率和品质，保障世界粮食安全，清原农冠在巴基斯坦开展了科学防除杂草的实验。实验证明，环吡氟草酮（cypyrafluone）能高效防除当地小籽虉草（Phalaris minor）等大部分小麦田杂草，帮助农民极大地节约种植成本。

清原农冠工作人员深入当地田间调研

       除环吡氟草酮（cypyrafluone）以外，双唑草酮（bipyrazone）也同步获得了巴基斯坦的批准登记。未来，三唑磺草酮（tripyrasulfone）、苯唑氟草酮（fenpyrazone）也将在巴基斯坦登记上市。双唑草酮（bipyrazone）、三唑磺草酮（tripyrasulfone）、苯唑氟草酮（fenpyrazone）均是清原农冠自主创制的全新HPPD抑制剂。双唑草酮（bipyrazone）可安全用于小麦田高效防除抗性及多抗性播娘蒿、荠菜、繁缕等阔叶杂草；三唑磺草酮（tripyrasulfone）是多抗性稗草、千金子的顶级解决方案，它首次将HPPD抑制剂安全用于水稻田苗后茎叶喷雾处理；苯唑氟草酮（fenpyrazone）对烟嘧磺隆抗性杂草马唐、稗草、红根谷莠子等不存在交互抗性，是玉米田优秀的ALS抑制剂抗性杂草管理方案。

双唑草酮、苯唑氟草酮、三唑磺草酮结构式

       此外，清原农冠已经在巴基斯坦、印尼、柬埔寨等6个东南亚国家开展农药登记，共22个登记项目，已经取得登记13个，还有9个正在进行中。

       据悉，截止到2021年11月底，清原集团已申请中国发明专利189件，已授权84件；已申请PCT国际发明专利113项，通过PCT途径或巴黎公约途径进入世界各国家累计达763件，累计已有157件获得授权。目前，清原农冠已在北美、欧洲、澳大利亚、南美、印度、东南亚等多个国家/地区开展了专利化合物实验。未来，清原农冠将继续把专利产品输送到更多国家，为世界粮食安全贡献中国力量。

随着清原农冠海外市场的开拓，我们急需有相关海外工作经验的专业性人才加入，同时，我们也希望与有相关需求的海外客户建立长期的战略合作关系，如有意向可联系清原徐经理。邮箱：xufeixiang@kingagroot.com。

Cypyrafluone was approved and registered by Pakistan, KingAgroot officially entered the overseas market

Recently, KingAgroot’s Cypyrafluone and other patented compounds were approved and registered by the Ministry of Agriculture of Pakistan, which is the first registration of this series of products overseas, marking the official start of KingAgroot foreign sales in the overseas market.

Cypyrafluone is a patent p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting herbicide, which was independently developed by KingAgroot. It was officially registered with the Ministry of Agriculture and Rural Affairs of the People's Republic of China on 30 August 2018. This is the first time that HPPD inhibitor be used to control grass weeds in wheat, and there is no cross-resistance with other wheat herbicides.

Pakistan has important strategic significance in the Asian market, thus KingAgroot chose Pakistan as the first overseas market. As we know, Pakistan is a typical agricultural country, mainly relies on crop farming, with wheat, rice and corn as major food crops. The wheat planting area accounts for about 40% of the country's total arable land. However, farmers are plagued by weeds such as Phalaris minor, which is highly resistant to local existing herbicides. Because of its vigorous growth and strong reproductive ability and fast expansion, this weed is seriously affecting the agricultural production in Pakistan.

In order to improve the efficiency and quality of world agricultural production and ensure world food security, KingAgroot has been carrying out scientific weed control trials in Pakistan. Data shows that Cypyrafluone can effectively control most weeds in wheat fields, especially local Phalaris minor, and help farmers greatly save planting costs.

In addition to Cypyrafluone, Bipyrazone was also registered in Pakistan. In the future, Tripyrasulfone and Fenpyrazone will also be registered and commercialized in Pakistan. Bipyrazone, Tripyrasulfone and Fenpyrazone are all new HPPD inhibitors developed by KingAgroot. Bipyrazone can be safely used to effectively control the resistant and multi-resistant broadleaf weeds such as flixweed, shepherd's-purse and chickweed. Tripyrasulfone is a top solution to multi-resistant barnyard grass and sprangletop. It is the first time that HPPD inhibitor is safely used in rice for post-emergence foliar spray treatment; Fenpyrazone is an excellent management tool for ALS-resistant weeds in maize such as crabgrass, barnyardgrass and foxtail resistant to Nicosulfuron because they have no cross-resistance.

Besides Pakistan, KingAgroot has been carrying out pesticide registrations in Indonesia, Cambodia and other Southeast Asia countries. KingAgroot has conducted 22 registration projects in overseas countries, 13 of them have obtained registration and 9 projects are under way.

As of the end of November 2021, KingAgroot has patented 189 Chinese inventions and 84 of them have been authorized; 113 PCT international inventions and accumulatively 763 have entered different countries in the world through PCT or The Paris Convention, while accumulatively 157 of them have been authorized. At present, KingAgroot’s patent compounds have been tested in North America, Europe, Australia, South America, India, Southeast Asia and other countries/regions. In the future, KingAgroot will continue to export its patented products to more countries and contribute to world food security.

With the development of the overseas market of KingAgroot, we are in urgent need of professional talents with relevant overseas working experience to join us. At the same time, we also hope to establish long-term strategic cooperative relationship with overseas customers. If you are interested, please contact Mr. Xu at: xufeixiang@kingagroot.com.